The Wahoo Burlington Depot, a two-story wood frame building on the Ashland-to-Schuyler line, was constructed in 1886, several months before the railroad's tracks were completed in 1887. Listed on the National Register of Historic Places, it was originally owned by the Omaha and North Platte Railroad Company and was leased to the Chicago, Burlington and Quincy Railroad in 1886, then deeded to the C.B.&Q. in 1908.

It was the last depot constructed in Wahoo, joining the Northwestern and Union Pacific depots in providing service to this area of Saunders County. The depot's main floor plan, which provided separate waiting rooms for men and women, is a variation of a nationally used pattern called the "combination" design. The second level was used for agent's living quarters. Closed in 1972, the depot is owned by the Saunders County Historical Society and used as a museum.